Gianotti-Crosti syndrome is parainfectious exanthematous disease having unique presentation of small papulovesicular eruptions symmetrically over extensor surface of sensory play limbs and face in children.Hemorrhagic lesions are very rare and are always localized.Here, a case of EBV-induced Gianotti-Crosti syndrome with extensive hemorrhagic vesic
Prediction of cardiorrespiratory fitness by screen time in schoolchildrens
The time spent in front of the screens, results in accumulations of sedentary behavior, which is related to health damages to adolescents, such as a low cardiorespiratory fitness.In this sense, this study aimed to predict cardiorespiratory fitness through screen time in schoolchildren.Cross-sectional study, as a sample Ashtrays composed of 2.764, o
MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.
Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase.Unexpectedly, we show that MHC II ubiquitination also impacts MHC I.Lack of MARCH1 in B cells and dendritic cells (DCs) Baggies resulted in a significant reduction in surface MHC I
MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.
Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase.Unexpectedly, we show that MHC II ubiquitination also impacts MHC I.Lack of MARCH1 in B cells and dendritic cells (DCs) Baggies resulted in a significant reduction in surface MHC I